CBD and your Liver: What does the research say?
Curtis Swift, Ph.D., Mesa Lavender Farms

The following is a recap of some of the articles on the National Institute of Health web site. The link to the research paper follows the abstract.

Cannabidiol has been shown to restore liver function:

  • Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057300/
  • Researchers demonstrated CBD treatment significantly reduced liver injury caused by chronic binge alcohol consumption in a mouse model and oxidative burst in human white blood cells. CBD improved alcohol-induced liver injury by reducing inflammation. These beneficial effects, coupled with proven safety of CBD in human clinical trials … suggest that it may have therapeutic potential in liver disease associated with inflammation, oxidative stress, metabolic dysregulation and steatosis (buildup of fat). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5608708/
  • Neurological and cognitive functions were severely impaired in thioacetamide-treated mice and were restored by cannabidiol.  Hepatic encephalopathy (HE) is a syndrome observed in patients with end-stage liver disease. Cannabidiol restored liver function, normalized 5-HT levels, and improved brain pathology in accordance with normalization of brain function.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057300/

Properly Dosed Cannabidiol reduces acute liver inflammation and damage

  • Researchers observed that CBD at 30 mg/kg (135 mg/10 lbs body weight) reduced acute liver inflammation and damage induced by cocaine and prevented associated seizure. Additionally, they showed previous liver damage induced by acetaminophen increased seizure and lethality induced by cocaine intoxication, linking hepatotoxicity to seizure dynamics. These findings suggest that activation of the cannabinoid system may have protective actions on both the liver and brain. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4427116/
  • CBD significantly reduced the extent of liver inflammation, oxidative/nitrative stress and cell death.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3081988/

CBD at exceptionally high doses can damage the liver.

  • In this toxicity study, liver damage did occur. The doses were exceptionally high with the highest CBD dose of 2460 mg/kg (11,070 mg/10 lbs body weight), causing clear evidence of liver damage. The 10-day sub-acute study also revealed that CBD doses above 50 mg/kg (225 mg/10 pounds body weight), although well tolerated after a single administration, were toxic when repetitively delivered.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6539990/

Note: Mesa Lavender Farms recommends a starting dose of 1 mg per 10 pounds of body weight per National Institute of Health Guidelines. At no time would we recommend anywhere near what was used in the research study showing liver damage. More is not always better.